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In Malignant Pleural Mesothelioma, New Mutations in Gene Identified,...
Frequent mutations in the SETDB1 gene and genome-wide alterations of allelic loss were identified in malignant pleural mesothelioma, according to results of a recent study, “Whole exome and targeted...
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Pleural Mesothelioma Genomic Analysis Finds Some 2,700 Functional Mutation in...
In a new comprehensive genomic study, researchers identified thousands of recurrent and protein-altering mutations in 216 malignant pleural mesothelioma (MPM) tumors. The analysis was performed using...
View ArticleSurvival Chances Rise in Peritoneal Mesothelioma Patients with Inactive BAP1...
Malignant peritoneal mesothelioma (MPM) patients often have mutations in their BAP1 gene or exhibit low levels of the protein. Researchers have now found that those patients with an inactive BAP1 have...
View ArticleNewly Identified Protein Variation May Make Mesothelioma More Vulnerable to...
A newly identified form of BRCA1-associated protein-1 (BAP1) increases malignant pleural mesothelioma cells’ vulnerability to some cancer therapies, a study indicates. The findings suggest a new...
View ArticleBreast, Ovarian Cancer Therapies Induce Malignant Pleural Mesothelioma Cell...
Tesaro (niraparib) and Lymparza (olaparib) — both PARP1 inhibitors approved by the U.S. Food and Drug Administration to treat breast and ovarian cancer patients — also kill malignant pleural...
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